Chitosan based fibrous absorbents for indoxyl sulfate sorption

Standard dialyzer membranes, designed for diffusive clearance, do not effectively clear protein-bound uremic toxins, such as indoxyl sulfate (IS). To increase toxins removal, absorbents require a high specific surface area to achieve effective size-coupling removal of target toxins. However, the toxicity molecule is necessarily determined by size alone. As proof concept, we report on an electrospun polycaprolactone/chitosan (PCL/CS) fibrous absorbent IS based chemical structural interaction. A single unit (20 mm in length) our PCL/CS achieved 28% clearance within hour at both 40 mg/L and 5 concentrations pass model. This structure offers new thoughts design.